KMID : 0366220170520040311
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Korean Journal of Hematology 2017 Volume.52 No. 4 p.311 ~ p.315
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Human parvovirus B19 and parvovirus 4 among Iranian patients with hemophilia
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Javanmard Davod
Ziaee Masood Ghaffari Hadi Namaei Mohammad Hasan Tavakoli Ahmad Mollaei Hamidreza Moghoofei Mohsen Mortazavi Helya Sadat Monavari Seyed Hamidreza
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Abstract
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Background: Human parvovirus B19 (B19V) is one of the smallest DNA viruses and shows great resist-ance to most disinfectants. Therefore, it is one of the common contaminant pathogens present in blood and plasma products. Parvovirus 4 (PARV4) is a newly identified parvovi-rus, which is also prevalent in parenteral transmission. In this study, we aimed to evaluate the prevalence of B19V and PARV4 DNA among patients with hemophilia in Birjand County in eastern Iran.
Methods: This was a cross-sectional epidemiological study comprising nearly all people with hemo-philia in this region. Whole blood samples were taken after patient registration and sent for plasma isolation. After nucleic acid extraction, B19V was detected with real-time poly-merase chain reaction, PARV4 DNA was then detected using sensitive semi-nested PCR.
Results: In total, there were 86 patients with hemophilia, with mean age 28.5¡¾1.5 years. Of these, 90.7% were men and 9.3% women; 84.9% had hemophilia A and 7.0% had hemophilia B. We found 11 patients (12.8%) were positive for B19V DNA and 8 were positive (9.3%) for PARV4 DNA. The prevalence of B19V was higher in middle-aged groups rather than younger people, whereas PARV4 infection was more common in younger patients (P£¼0.05).
Conclusion: There was a high prevalence of B19V and PARV4 infection in this high-risk group of pa-tients with hemophilia. Due to the clinical significance of the B19 virus, imposing more precautionary measures for serum and blood products is recommended.
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KEYWORD
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Parvovirus B19, PARV4, Hemophilia, Prevalence, Iran
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